Biochemistry, B.S. Requirements

Program Director:Marilena Hall (Sabbatical, Spring 2017) Office: Shields Science Center 211 Phone: 508-565-1182mhall@stonehill.eduLouis Liotta (Acting Program Director, Spring 2017) Office: Shields Science Center 315 Phone: 508-565-1043lliotta@stonehill.edu

The Biochemistry major conforms to the recommendations of the American Society of Biochemistry and Molecular Biology, and the American Chemical Society. Through a rigorous course of study with a strong emphasis on the learn-by-doing approach, the Biochemistry Program is committed to providing the practical knowledge and skills necessary for graduate study in biochemistry, chemistry, molecular biology, genetics and biotechnology, or admission to professional school. It will also enable students to obtain skilled technical positions after graduation in research laboratories in universities, biotechnology or pharmaceutical development industries, hospitals and government agencies. Juniors and seniors are encouraged to apply for off-campus internships in biochemistry. In addition, each junior and senior Biochemistry major presents two program seminars covering information from the current biochemical literature as well as writing and defending a senior thesis, usually relating to research they have completed.

The course of study normally pursued by Biochemistry majors is:

First Year

Code Course Credits

BIO 101

Biological Principles I     1

Offered: Fall Semester

An introduction to the concepts of molecular biology, the cell, energetics and genetics.

Fulfills the Natural Scientific Inquiry requirement.

4

CHM 113

General Chemistry I

Offered: Fall and Spring Semesters

The fundamentals of chemistry are covered including: matter and measurement, atomic structure and the periodic table, chemical reactions and stoichiometry, chemical bonding, thermodynamics, and an introduction to chemical kinetics and equilibrium.

Fulfills the Natural Scientific Inquiry requirement.

4

MTH 125

Calculus I

Offered: Fall and Spring Semesters

Calculus of a single variable: functions, limits, derivatives, differentiation rules, applications of derivatives, integrals, techniques of integration, applications of integration, infinite sequences and series, first and second order differential equations. May not receive credit for both MTH 125 and MTH 119.

4

BIO 102

Biological Principles II

Offered: Spring Semester

An introduction to the principles of evolution, biodiversity, and ecology.

Prerequisite(s): BIO 101.
Fulfills the Natural Scientific Inquiry requirement.

4

CHM 221

Organic Chemistry I

Offered: Spring Semester

The basics of organic chemistry are covered including: structure and bonding of alkanes, alkenes, aromatic hydrocarbons and alkynes; functional groups containing heteroatoms; chromatography; spectroscopy; stereochemistry; methods of studying organic reaction; and an introduction to mechanisms of organic reactions.

Prerequisite(s): CHM 113 (with a grade of C- or better - starts with the Class of 2019).

4

MTH 126

Calculus II

Offered: Fall and Spring Semesters

Calculus of a single variable: functions, limits, derivatives, differentiation rules, applications of derivatives, integrals, techniques of integration, applications of integration, infinite sequences and series, first and second order differential equations.

Prerequisite(s): Prerequisite for MTH 126: MTH 125.

4

Sophomore Year

Code Course Credits

BIO 211

Cell Biology (WID)     (Recommended to take with LC 209 - Learning Community: Organic Chemistry of the Cell)

Offered: Fall Semester

An overview of eukaryotic cell structure and function. Topics include: mechanisms of protein processing, vesicular transport, intercellular and intracellular communication; cell cycle regulation; cell proliferation, differentiation and programmed cell death. (CORE)

Prerequisite(s): BIO 101 and BIO 102 (with a grade of C- or above - starting with the Class of 2019).
Fulfills the Writing-in-the-Disciplines requirement for Biology and Neuroscience majors.

4

CHM 222

Organic Chemistry II

Offered: Fall Semester

The mechanistic and synthetic organic chemistry relating to nucleophilic substitution, elimination, additions to carbon-carbon multiple bonds, aromatic substitution, addition and substitution at carbonyls, substitution alpha to carbonyls, rearrangements, and polymerizations. The organic chemistry of natural compounds (e.g. peptides, carbohydrates, etc.) is introduced.

Prerequisite(s): CHM 221 (with a grade of C- or better - starts with the Class of 2019).

4

PHY 121

Physics I

Offered: Fall Semester

Brief introduction to vectors and basic concepts of calculus; kinematics; Newton’s laws, force, work and power; conservative forces, potential energy; momentum, collisions; rotational motion, angular momentum, torque; oscillations, simple harmonic motion; gravitation and planetary motion; fluid dynamics; kinetic theory of gases, thermodynamics; heat capacity and transport.

Corequisite(s): MTH 125.

4

BIO 212

Genetics

Offered: Spring Semester

Classical genetics of eukaryotes, the biochemistry of gene function, regulation of gene expression, mutation and repair, and genetics of prokaryotes and viruses. Laboratory work stresses classical and molecular genetics research techniques. (CORE)

Prerequisite(s): BIO 101, BIO 102 and BIO 211

4

CHM 244

Inorganic Chemistry

Offered: Spring Semester

This course covers fundamentals of central topics in inorganic chemistry from historical to modern-day perspectives. Topics include: Coordination compounds (history, structure, bonding theories, reactivity, applications); solid state chemistry (crystals, lattices, radius ratio rule, defect structures, silicates & other minerals); and descriptive chemistry of the elements.

Prerequisite(s): CHM 222 (with a grade of C- or better - starts with the Class of 2019).

4

PHY 122

Physics II

Offered: Spring Semester

Brief introduction to the basic concepts of vector calculus, such as line and surface integrals, integral version of Gauss’ theorem and Stokes’ theorem; Coulomb’s law, insulators and metals; electrostatic induction, potential energy; capacitance; currents, resistance, basic circuits, batteries; magnetism and currents; Ampere’s law; motion of free charges in magnetic fields, mass spectroscopy; magnetic induction, Faraday’s law; Maxwell’s equations, electromagnetic waves; geometric and wave optics; light as photons, photoelectric effect.

Prerequisite(s): MTH 125
Corequisite(s): MTH 126.

4

Junior Year

Code Course Credits

BCH 343

Biochemistry I

Offered: Fall Semester

Structure and dynamics of amino acids, peptides and proteins. Enzyme mechanisms and kinetics. Function and mechanisms of coenzymes, survey of carbohydrates, lipids, biological membranes and nucleic acids. An introduction to the bioenergetics and mechanisms of metabolism.

Corequisite(s): CHM 222.

3

BCH 447

Junior Fall Biochemistry Seminar     3

Offered: Fall Semester

Third-year Biochemistry majors meet with Chemistry and Biochemistry faculty once a week for both internal and external seminars. Each student is required to prepare and present a half-hour seminar on a topic of his/her choice found in a current professional journal. All students are expected to attend and provide professional evaluations of other students' seminar presentations.

Prerequisite(s): Junior Biochemistry majors only.
Students will earn four credits in the second semester senior year upon successful completion of BCH 447, BCH 448, BCH 449, and BCH 450 .

Zero

BIO 304

Molecular Biology     (or BIO 309 in Spring)

Offered: Fall Semester

This course provides an in-depth coverage of advanced cell and molecular genetics topics, expanding on fundamental topics covered in BIO 212 - Genetics . It reviews modern molecular biology techniques with emphasis on experimental design and data analysis. It incorporates material from the textbook and from current scientific literature. The laboratory portion introduces molecular techniques like cloning, site-directed mutagenesis, and RFLP.

Prerequisite(s): BIO 101, BIO 211, BIO 212 and CHM 222.
This course fulfills the Molecular/Cellular requirement.

4

CHM 301

Professional Ethics in Chemistry and Biochemistry     2

Offered: Fall Semester

Discussion and resolution of ethical problems and safety associated with the fields of chemistry and biochemistry will be explored. Topics include: responsible treatment of data, reporting scientific information, responsibilities of the peer review system, conflicts of interest, relationship of chemistry to society and its impact on public health and the environment, and issues of safety in the laboratory.

Prerequisite(s): CHM 222 and Junior standing.
Fulfills the Moral Inquiry requirement.

3

CHM 333

Physical Chemistry I

Offered: Fall Semester

This course provides in-depth exploration of key chemistry topics in thermodynamics and kinetics. Topics include: gas laws, energy transfer, phase equilibrium, chemical potential, properties of solutions, and kinetic theory and mechanism. Specific applications of physical chemistry are given in terms of material science, nanoscience, biochemistry, environmental chemistry, and technology.

Prerequisite(s): MTH 126 & CHM 232 or CHM 244

4

BCH 344

Biochemistry II

Offered: Spring Semester

A comprehensive examination of metabolism of carbohydrates, lipids, proteins and nucleic acids.

Prerequisite(s): BCH 343.

3

BCH 345

Biochemistry Laboratory (WID)     4

Offered: Spring Semester

The course applies both classical and modern biochemical techniques to the characterization of amino acids, the purification of proteins, the analysis of enzyme kinetics, and the study of DNA denaturation.

Prerequisite(s): BCH 343.
Fulfills the Writing-in-the-Disciplines requirement.

4

BCH 448

Junior Spring Biochemistry Seminar     3

Offered: Spring Semester

Third-year Biochemistry majors meet with Chemistry and Biochemistry faculty once a week for both internal and external seminars. All students are expected to attend and provide professional evaluations of other students' seminar presentations.

Prerequisite(s): BCH 447.
Students will earn four credits in the second semester senior year upon successful completion of BCH 447, BCH 448, BCH 449, and BCH 450 .

Zero

BIO 309

Microbiology     (or BIO 304 in Fall)

Offered: Spring Semester

A survey of microorganisms with emphasis on bacteria. Topics include: microbial cell biology, growth, metabolism, and genetics; control of microbial growth; host-microbe interactions; and environmental microbiology.

Prerequisite(s): BIO 101, BIO 102, BIO 211 and Junior and Senior standing.
This course fulfills either the Molecular/Cellular or Organismal requirement.

4

CHM 331

Analytical Chemistry     5

Offered: Spring Semester

This course provides an in-depth study of chemical equilibrium in acid-base, complexation, oxidation-reduction and precipitation reactions, as well as incorporates a survey of analytical instrumentation. Quantitative analysis methods, including titrations, spectroscopy, chromatography, and potentiometry, are discussed and performed with rigorous statistical evaluation of experimental data in a 4-hour weekly laboratory session.

Prerequisite(s): CHM 221 (with a grade of C- or better - starts with the Class of 2019)..
Fulfills the Statistical Reasoning requirement.

4

Senior Year

Code Course Credits

BCH 449

Senior Fall Biochemistry Seminar     3

Offered: Fall Semester

Fourth-year Biochemistry majors meet with Chemistry and Biochemistry faculty once a week for both internal and external seminar presentations. During the fall semester of the fourth year each student is required to prepare and present a half-hour seminar on a topic of his/her choice found in a current professional journal. All students are expected to attend and provide professional evaluations of other students' seminar presentations. During the fall semester, each fourth-year student will be expected to start writing a thesis. Preferably this thesis will cover experimental or theoretical research the student has actually done.

Prerequisite(s): BCH 448.
Students will earn four credits in the second semester senior year upon successful completion of BCH 447, BCH 448, BCH 449 and BCH 450.

Zero

BCH 450

Senior Spring Biochemistry Seminar & Thesis

Offered: Spring Semester

Fourth-year Biochemistry majors meet with Chemistry and Biochemistry faculty once a week for both internal and external seminar presentations. All students are expected to attend and provide professional evaluations of other students' seminar presentations. Each fourth-year student will be expected to write and defend his/her thesis in the spring semester of the fourth year.

Prerequisite(s): BCH 449.
Students will earn four credits in the second semester senior year upon successful completion of BCH 447, BCH 448, BCH 449, and BCH 450.

4

Notations

1 Fulfills the Natural Scientific Inquiry requirement of the Cornerstone Program.2 Fulfills the Moral Inquiry requirement of the Cornerstone Program.3 Required in each semester of the junior and senior years and satisfies the Capstone Experience requirement of the Cornerstone Program. Four credits are obtained in the second semester of the senior year.4 Fulfills the Writing-in-the-Disciplines requirement of the Cornerstone Program.5 Fulfills the Statistical Reasoning requirement of the Cornerstone Program.

Biochemistry Honors

Students who complete the honors requirements in Biochemistry below will be awarded a degree "with honors in Biochemistry."

  • an overall GPA of at least 3.40; and
  • a science (Biochemistry, Biology and Chemistry) GPA of at least 3.40.
  • conduct research approved by the Program Director; and earn at least a "B+" on both the thesis and thesis defense required for BCH 450 - Senior Spring Biochemistry Seminar & Thesis. This thesis will be based on thesis research, internship, S.U.R.E. project, or other college-level research experience.

Contact Professor Marilena Hall, Biochemistry Program Director, for additional details and deadlines.

American Chemical Society Certification

Biochemistry majors desiring an American Chemical Society certified degree must have at least 76 hours of additional, for credit, chemistry or biochemistry laboratory experience over the laboratory experience associated with the courses specifically required for the biochemistry major. Contact Professor Marilena Hall, Biochemistry Program Director, for more information.